• Recently published: Epigenetic dynamics of monocyte-to-macrophage differentiation

    August 01, 2016

    Several members of DEEP have published an article in the Epigenetics & Chromatin that deals with the epigenetic dynamics of monocyte-to-macrophage differentiation. In order to elucidate the role of gene regulatory changes during the differentiation process, the authors used high-throughput sequencing to analyze the complete transcriptome and epigenome of human monocytes. They discovered a...


  • Recently published: DeepBlue epigenomic data server: programmatic data retrieval and analysis of epigenome region sets

    April 25, 2016

    Alongside with other authors, DEEP member Thomas Lengauer published a paper to present the DeepBlue Epigenomic Data Server. It provides a comprehensive programmatic interface for finding, selecting, filtering, summarizing and downloading region sets. The server contains data of the DEEP project, as well as of three other epigenome projects: ENCODE, ROADMAP and BLUEPRINT. With DeepBlue, the...


  • Recently published: deepTools2: a next generation web server for deep-sequencing data analysis

    April 15, 2016

    Alongside with other colleagues, scientists from the Max Planck Institute of Immunobiology and Epigentics, a DEEP partner, published a paper on their tools for processing and visualizing deeply sequenced data, called deepTools2. It presents an update of a Galaxy-based web server which allows its users to perform complete bioinformatic workflows. Many enhancements have been implemented since the...


  • Epigenetic switch turns obesity On or Off

    February 01, 2016

    It is well known that a predisposition to adiposity lies in our genes. A new study by researchers lead by Andrew Pospisilik, a member of the DEEP project, now shows that epigenetic changes play a key role in the inheritance of obesity. The scientists at the Max Planck Institute of Immunobiology and Epigenetics in Freiburg discovered an epigenetic switch, which causes individuals with identical...


  • Recently published: Standardizing chromatin research - a simple and universal method for ChIP-seq

    January 12, 2016

    DEEP member Thomas Manke, together with colleagues from the Max Planck Institute of Immunobiology and Epigenetics and the Luxembourg Centre for Systems Biomedicine, recently published a paper on the harmonization of ChIP-seq workflows. The paper presents an ultrasound-based nuclei extraction method that is highly effective across various organisms, cell types and cell numbers. The described...


  • Epigenetics 2015 – Keynote Lecture by Jörn Walter

    December 10, 2015

    From 12-14 November, the 6th Australian Epigenetics Alliance flagship conference “Epigenetics 2015” hosted international and national leaders in the field of epigenetics in Hobart, Australia. DEEP-coordinator Jörn Walter was invited to present a key note lecture titled “Epigenomics – from mapping to functional interpretation” at the conference. See also a discussion of his talk in the...


  • Epigenetics made easy

    December 03, 2015

    The Epigenetics Research Laboratory at the Garvan Institute in Sydney has released the last two in a series of four sketch videos about epigenetics. The videos, created by Armando Hasudungan in collaboration with Professor Susan Clark and Dr Kate Patterson, highlight key messages about the role epigenetics plays in biological processes like development and diseases such as cancer. Watch the...