Recently published: Epigenetic dynamics of monocyte-to-macrophage differentiation
Several members of DEEP have published an article in the Epigenetics & Chromatin that deals with the epigenetic dynamics of monocyte-to-macrophage differentiation. In order to elucidate the role of gene regulatory changes during the differentiation process, the authors used high-throughput sequencing to analyze the complete transcriptome and epigenome of human monocytes. They discovered a phagocytic gene network that is repressed by DNA methylation in monocytes and rapidly de-repressed after the onset of macrophage differentiation.
The article can be openly accessed in Epigenetics & Chromatin.